Plants have developed extraordinary capabilities to detect and respond to changes in their environment. These changes often manifest as alterations to plant biochemistry and frequently involve pathways related to health-beneficial compounds. As controlled environment agriculture becomes an increasingly dominant part of our food supply, we see opportunities to find novel ways that growers can enhance the health-promoting properties of fruits and vegetables while maintaining adequate yield, shelf life, etc. We are also improving our capacity to intrinsically label crops to provide invaluable material that can be used to answer cutting-edge nutritional questions. The Dzakovich Lab has produced a number of custom-built technologies to label plants using 13CO2, heavy water, and/or isotopes of minerals.